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Article

Proteochemometric modeling of the susceptibility of mutated variants of the HIV-1 virus to reverse transcriptase inhibitors.

PloS one - 15 Dec 2010

Junaid Muhammad, Lapins Maris, Eklund Martin, Spjuth Ola, Wikberg Jarl E S

Abstract excerpt

BACKGROUND: Reverse transcriptase is a major drug target in highly active antiretroviral therapy (HAART) against HIV, which typically comprises two nucleoside/nucleotide analog reverse transcriptase (RT) inhibitors (NRTIs) in combination with a non-nucleoside RT inhibitor or a protease inhibitor. Unfortunately, HIV is capable of escaping the therapy by mutating into drug-resistant variants. Computational models...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21179544
DOI: 10.1371/journal.pone.0014353
PMCID: PMC3002298

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