Article
Colocalization of Wnt/β-Catenin and ACTH Signaling Pathways and Paracrine Regulation in Aldosterone-producing Adenoma.
The Journal of clinical endocrinology and metabolism - 18 Jan 2022
De Sousa Kelly, Abdellatif Alaa B, Giscos-Douriez Isabelle, Meatchi Tchao, Amar Laurence, Fernandes-Rosa Fabio L, Boulkroun Sheerazed, Zennaro Maria-Christina
Abstract excerpt
CONTEXT: Aldosterone-producing adenomas (APAs) are a common cause of primary aldosteronism (PA). Despite the discovery of somatic mutations in APA and the characterization of multiple factors regulating adrenal differentiation and function, the sequence of events leading to APA formation remains to be determined. OBJECTIVE: We investigated the role of Wnt/β-catenin and adrenocorticotropin signaling, as well as...
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