Article
The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes.
Scientific reports - 19 Jan 2017
Wu Vin-Cent, Wang Shuo-Meng, Chueh Shih-Chieh Jeff, Yang Shao-Yu, Huang Kuo-How, Lin Yen-Hung, Wang Jian-Jhong, Connolly Rory, Hu Ya-Hui, Gomez-Sanchez Celso E, Peng Kang-Yung, Wu Kwan-Dun
Abstract excerpt
Constitutive activation of the Wnt pathway/β-catenin signaling may be important in aldosterone-producing adenoma (APA). However, significant gaps remain in our understanding of the prevalence and clinical outcomes after adrenalectomy in APA patients harboring CTNNB1 mutations. The molecular expression of CYP11B2 and gonadal receptors in adenomas were also explored. Adenomas from 219 APA patients (95 men; 44.2%;...
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