Article
Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors.
The Journal of clinical endocrinology and metabolism - 1 Oct 2008
Gaujoux Sébastien, Tissier Frédérique, Groussin Lionel, Libé Rossella, Ragazzon Bruno, Launay Pierre, Audebourg Anne, Dousset Bertrand, Bertagna Xavier, Bertherat Jérôme
Abstract excerpt
BACKGROUND: The Wnt/beta-catenin and cAMP signaling pathways play an important role in adrenal cortex tumorigenesis. Somatic activating mutations of the beta-catenin gene (CTNNB1) are the most frequent genetic defects identified both in adrenocortical adenomas (ACAs) and adrenocortical cancers (ACCs). PRKAR1A mutations leading to cAMP pathway dysregulation are observed in primary pigmented nodular adrenocortical...
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