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Article

Mutational landscape of non-functional adrenocortical adenomas.

Endocrine-related cancer - 1 Sept 2022

Wu Luming, Xie Jing, Qi Yan, Su Tingwei, Jiang Lei, Zhou Weiwei, Jiang Yiran, Zhang Cui, Zhong Xu, Cao Yanan, Wang Weiqing

Abstract excerpt

Adrenal incidentalomas are the most frequent human neoplasms. Recent genomic investigations on functional adrenocortical tumors have demonstrated that somatic mutations in PRKACA and KCNJ5 responsible for the development of adrenocortical adenomas (ACAs) are associated with hypercortisolism and aldosteronism, respectively. Several studies have identified CTNNB1 mutations in ACAs and have been mostly involved in...

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PMID: 35731037
DOI: 10.1530/ERC-21-0410

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