Article
HLA-G 3'UTR haplotype frequencies in highland and lowland South Native American populations.
Human immunology - 1 Jan 2022
Jacovas Vanessa Cristina, Michita Rafael Tomoya, Bisso-Machado Rafael, Reales Guillermo, Tarazona-Santos Eduardo M, Sandoval José Raul, Salazar-Granara Alberto, Chies José Artur Bogo, Bortolini Maria Cátira
Abstract excerpt
Human Leukocyte Antigen (HLA)-G participates in several biological processes, including reproduction, vascular remodeling, immune tolerance, and hypoxia response. HLA-G is a potential candidate gene for high altitude adaptation since its expression is modulated in both micro and macro environment under hypoxia and constant cellular stress. Besides the promoter region, the HLA-G 3'untranslated region (UTR)...
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