Article
Endothelin-1 gene variants and levels associate with adaptation to hypobaric hypoxia in high-altitude natives.
Biochemical and biophysical research communications - 24 Mar 2006
Rajput Charu, Najib Shehla, Norboo Tsering, Afrin Farhat, Qadar Pasha M A
Abstract excerpt
High-altitude natives are adapted to hypobaric hypoxia, suggestive of genetic basis of adaptation. Since endothelin-1 (ET-1) is of prime importance in high-altitude disorders in sojourners, we envisaged the role of allelic variants of ET-1 in high-altitude adaptation. Four ET-1 polymorphisms, viz., (CT)(n)-(CA)(n) repeat, -3A/-4A, G2288T, and Lys198Asn, were investigated in 426 highlanders (HLs) and 236...
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