Article
Signatures of high-altitude adaptation in Caucasus populations: evidence from the EGLN1-SPRTN locus.
Genetica - 16 Jan 2026
Dzhaubermezov Murat A, Ekomasova Natalia V, Akhmetshin Askar A, Atabiev Biyaslan Kh, Chagarov Ongar S, Gabidullina Liliya R, Sufyanova Zemfira R, Fedorova Yuliya Yu, Nurgalieva Alfiia Kh, Prokofyeva Darya S, Miziev Ismail A, Chekanov Nikolay N, Khusnutdinova Elza K
Abstract excerpt
High-altitude hypoxia refers to the state of reduced oxygen availability experienced at high elevations, which poses significant physiological challenges. Genetic adaptations to this condition involve mutations in various genes that regulate oxygen sensing, erythropoiesis, and metabolic processes, enabling populations indigenous to high-altitude regions to maintain adequate tissue oxygenation and metabolic...
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