Article

AlphaFold3 and RoseTTAFold All-Atom structures enable radiosensitizers discovery by targeting multiple DNA damage repair proteins

2025-03-29

Abstract excerpt

Radioresistance remains a primary obstacle in tumor radiotherapy, with no clinically approved radiosensitizers due to toxicity concerns. To identify effective and safe radiosensitizers, a natural products database containing 79,263 compounds are docked against a hybrid target library of four DNA damage response (DDR)-related proteins, comprising both experimental and artificial intelligence (AI)-predicted structur...

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Literature Corpus work: e6da0b0f-4b8f-5ff2-9047-eecdb02e18c5
DOI: 10.1101/2025.03.26.645385

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