Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Aug 2017

Jacob Chaim O, Yu Ning, Yoo Dae-Goon, Perez-Zapata Lizet J, Barbu Emilia Alina, Kaplan Mariana J, Purmalek Monica, Pingel Jeanette T, Idol Rachel A, Dinauer Mary C

Abstract excerpt

OBJECTIVE: We have previously established that the gene for neutrophil cytosolic factor 2 (NCF-2) predisposes to lupus, and we have identified lupus patients with point mutations that are predicted to cause reduced NADPH oxidase activity. We undertook this study to investigate the relationship between reduced leukocyte NADPH oxidase activity and immune dysregulation associated with systemic lupus erythematosus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Cationic Peptides
Share to Aspergillus fumigatus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cathelicidins

Share to Extracellular Traps

Share to Granulomatous Disease, Chronic

Share to Haploinsufficiency

Share to Interferon Type I

Share to Lupus Nephritis

Source

Identifiers

PMID: 28471497
DOI: 10.1002/art.40141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice.PMID 28471497Read ↗

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.Semantic proximity Read ↗

Finding causative genes underlying rheumatic disease: could NCF1 pave the way?Semantic proximity Read ↗

Neutrophil cytosolic factor 2 (NCF2) gene polymorphism is associated with juvenile-onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children.Semantic proximity Read ↗

Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice.Semantic proximity Read ↗

Inherited p40phox deficiency differs from classic chronic granulomatous disease.Semantic proximity Read ↗

Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.Semantic proximity Read ↗

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.Semantic proximity Read ↗

Genetics of SLE: evidence from mouse models.Semantic proximity Read ↗

Neutrophil Extracellular Trap Formation and Complement Activation Pathways Dominate Microbiota-dependent disease bias in lupus-prone female NZM2328 miceSemantic proximity Read ↗

A Founder Effect of c.257 + 2T > C Mutation in NCF2 Gene Underlies Severe Chronic Granulomatous Disease in Eleven Patients.Semantic proximity Read ↗

Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice.Semantic proximity Read ↗

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.