Article
Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2012
Jacob Chaim O, Eisenstein Miriam, Dinauer Mary C, Ming Wenyu, Liu Qiang, John Sutha, Quismorio Francesco P, Reiff Andreas, Myones Barry L, Kaufman Kenneth M, McCurdy Deborah, Harley John B, Silverman Earl, Kimberly Robert P, Vyse Timothy J, Gaffney Patrick M, Moser Kathy L, Klein-Gitelman Marisa, Wagner-Weiner Linda, Langefeld Carl D, Armstrong Don L, Zidovetzki Raphael
Abstract excerpt
Systemic lupus erythematosus (SLE), the prototypic systemic autoimmune disease, is a debilitating multisystem autoimmune disorder characterized by chronic inflammation and extensive immune dysregulation in multiple organ systems, resulting in significant morbidity and mortality. Here, we present a multidisciplinary approach resulting in the identification of neutrophil cytosolic factor 2 (NCF2) as an important...
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