Article
Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae.
Molecular biology of the cell - 1 Jul 2000
Tsubouchi H, Ogawa H
Abstract excerpt
The MRE11, RAD50, and XRS2 genes of Saccharomyces cerevisiae are involved in the repair of DNA double-strand breaks (DSBs) produced by ionizing radiation and by radiomimetic chemicals such as methyl methanesulfonate (MMS). In these mutants, single-strand DNA degradation in a 5' to 3' direction from DSB ends is reduced. Multiple copies of the EXO1 gene, encoding a 5' to 3' double-strand DNA exonuclease, were found...
Topics
- Crossing Over, Genetic
- DNA Damage
- DNA Repair
- DNA, Fungal
- Endodeoxyribonucleases
- Exodeoxyribonucleases
- Fungal Proteins
- Genes, Fungal
- Meiosis
- Methyl Methanesulfonate
- Phenotype
- Plasmids
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Spores, Fungal
- Telomere
- Transcription, Genetic