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Article

Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism.

Genetics - 1 Dec 2001

Moreau S, Morgan E A, Symington L S

Abstract excerpt

MRE11 functions in several aspects of DNA metabolism, including meiotic recombination, double-strand break repair, and telomere maintenance. Although the purified protein exhibits 3' to 5' exonuclease and endonuclease activities in vitro, Mre11 is implicated in the 5' to 3' resection of duplex ends in vivo. The mre11-H125N mutation, which eliminates the nuclease activities of Mre11, causes an accumulation of...

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Source

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Identifiers

PMID: 11779786
DOI: 10.1093/genetics/159.4.1423
PMCID: PMC1461908

Genes

EXO1
MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism.PMID 11779786Read ↗

Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.Semantic proximity Read ↗

Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae.Semantic proximity Read ↗

Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance.Semantic proximity Read ↗

Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Mre11 nuclease is not required for 5' to 3' resection at multiple HO-induced double-strand breaks.Semantic proximity Read ↗

The Saccharomyces cerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functions.Semantic proximity Read ↗

Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability.Semantic proximity Read ↗

Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.Semantic proximity Read ↗

Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity.Semantic proximity Read ↗

The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.Semantic proximity Read ↗

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