Article

A Serum- and Feeder-Free System to Generate CD4 and Regulatory T Cells from Human iPSCs

2023-07-02

Abstract excerpt

iPSCs can serve as a renewable source of a consistent edited cell product, overcoming limitations of primary cells. While feeder-free generation of clinical grade iPSC-derived CD8 T cells has been achieved, differentiation of iPSC-derived CD4sp and regulatory T cells requires mouse stromal cells in an artificial thymic organoid. Here we report a serum- and feeder-free differentiation process suitable for large-sca...

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Literature Corpus work: e76511c4-e6bc-5c2b-8df2-6d3804d5188b
DOI: 10.1101/2023.07.01.547333

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