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Article

mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote KrasG12D-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis.

Gastroenterology - 1 Apr 2021

Zhao Yamin, Schoeps Benjamin, Yao Dianbo, Zhang Zhiheng, Schuck Kathleen, Tissen Vivien, Jäger Carsten, Schlitter Anna Melissa, van der Kammen Rob, Ludwig Christina, D'Haese Jan G, Raulefs Susanne, Maeritz Nadja, Shen Shanshan, Zou Xiaoping, Krüger Achim, Kleeff Jörg, Michalski Christoph W, Friess Helmut, Innocenti Metello, Kong Bo

Abstract excerpt

BACKGROUND & AIMS: Oncogenic KrasG12D induces neoplastic transformation of pancreatic acinar cells through acinar-to-ductal metaplasia (ADM), an actin-based morphogenetic process, and drives pancreatic ductal adenocarcinoma (PDAC). mTOR (mechanistic target of rapamycin kinase) complex 1 (mTORC1) and 2 (mTORC2) contain Rptor and Rictor, respectively, and are activated downstream of KrasG12D, thereby contributing...

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Identifiers

PMID: 33388318
DOI: 10.1053/j.gastro.2020.12.061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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