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Article

Common determinants in DNA melting and helicase-catalysed DNA unwinding by papillomavirus replication protein E1.

Nucleic acids research - 1 Jan 2006

Castella Sandrine, Bingham Gregg, Sanders Cyril M

Abstract excerpt

E1 and T-antigen of the tumour viruses bovine papillomavirus (BPV-1) and Simian virus 40 (SV40) are the initiator proteins that recognize and melt their respective origins of replication in the initial phase of DNA replication. These proteins then assemble into processive hexameric helicases upon the single-stranded DNA that they create. In T-antigen, a characteristic loop and hairpin structure (the pre-sensor...

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Identifiers

PMID: 16738139
DOI: 10.1093/nar/gkl384
PMCID: PMC1474052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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