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Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy

20 Sept 2021

Abstract excerpt

cells for infection with two different viruses: mumps virus and influenza A virus, respectively. Independent screening results converged on the endocytosis pathway and the protein secretory pathway as required for both viral infections. Additionally, we revealed a general dependence of the C1-tetrahydrofolate synthase gene, MTHFD1, for viral replication in bat cells and human cells. The MTHFD1 inhibitor,...

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PMID: 34544865
DOI: 10.1073/pnas.2104759118

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