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Identification of Cellular Proteins Required for Replication of Human Immunodeficiency Virus Type 1

10 Mar 2012

Abstract excerpt

Cellular proteins are essential for human immunodeficiency virus type 1 (HIV-1) replication and may serve as viable new targets for treating infection. Using gene trap insertional mutagenesis, a high-throughput approach based on random inactivation of cellular genes, candidate genes were found that limit virus replication when mutated. Disrupted genes (N=87) conferring resistance to lytic infection with several...

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PMID: 22404213
DOI: 10.1089/aid.2011.0358

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