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The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection

6 Feb 2014

Abstract excerpt

The Bunyaviridae comprise a large family of RNA viruses with worldwide distribution and includes the pathogenic New World hantavirus, Andes virus (ANDV). Host factors needed for hantavirus entry remain largely enigmatic and therapeutics are unavailable. To identify cellular requirements for ANDV infection, we performed two parallel genetic screens. Analysis of a large library of insertionally mutagenized human...

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PMID: 24516383
DOI: 10.1371/journal.ppat.1003911

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