Article
Genome-wide siRNA Screening at Biosafety Level 4 Reveals a Crucial Role for Fibrillarin in Henipavirus Infection.
PLoS pathogens - 1 Mar 2016
Deffrasnes Celine, Marsh Glenn A, Foo Chwan Hong, Rootes Christina L, Gould Cathryn M, Grusovin Julian, Monaghan Paul, Lo Michael K, Tompkins S Mark, Adams Timothy E, Lowenthal John W, Simpson Kaylene J, Stewart Cameron R, Bean Andrew G D, Wang Lin-Fa
Abstract excerpt
Hendra and Nipah viruses (genus Henipavirus, family Paramyxoviridae) are highly pathogenic bat-borne viruses. The need for high biocontainment when studying henipaviruses has hindered the development of therapeutics and knowledge of the viral infection cycle. We have performed a genome-wide siRNA screen at biosafety level 4 that identified 585 human proteins required for henipavirus infection. The host protein...
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