Article
Broad sarbecovirus neutralization by a human monoclonal antibody.
Nature - 1 Sept 2021
Tortorici M Alejandra, Czudnochowski Nadine, Starr Tyler N, Marzi Roberta, Walls Alexandra C, Zatta Fabrizia, Bowen John E, Jaconi Stefano, Di Iulio Julia, Wang Zhaoqian, De Marco Anna, Zepeda Samantha K, Pinto Dora, Liu Zhuoming, Beltramello Martina, Bartha Istvan, Housley Michael P, Lempp Florian A, Rosen Laura E, Dellota Exequiel, Kaiser Hannah, Montiel-Ruiz Martin, Zhou Jiayi, Addetia Amin, Guarino Barbara, Culap Katja, Sprugasci Nicole, Saliba Christian, Vetti Eneida, Giacchetto-Sasselli Isabella, Fregni Chiara Silacci, Abdelnabi Rana, Foo Shi-Yan Caroline, Havenar-Daughton Colin, Schmid Michael A, Benigni Fabio, Cameroni Elisabetta, Neyts Johan, Telenti Amalio, Virgin Herbert W, Whelan Sean P J, Snell Gyorgy, Bloom Jesse D, Corti Davide, Veesler David, Pizzuto Matteo Samuele
Abstract excerpt
The recent emergence of SARS-CoV-2 variants of concern1-10 and the recurrent spillovers of coronaviruses11,12 into the human population highlight the need for broadly neutralizing antibodies that are not affected by the ongoing antigenic drift and that can prevent or treat future zoonotic infections. Here we describe a human monoclonal antibody designated S2X259, which recognizes a highly conserved cryptic...
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