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Article

Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy

6 May 2019

Abstract excerpt

The transcription factor Oct1/Pou2f1 promotes poised gene expression states, mitotic stability, glycolytic metabolism and other characteristics of stem cell potency.To determine the effect of Oct1 loss on stem cell maintenance and malignancy, we deleted Oct1 in two different mouse gut stem cell compartments.Oct1 deletion preserved homeostasis in vivo and the ability to establish organoids in vitro, but blocked...

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PMID: 31059499
DOI: 10.1371/journal.pgen.1007687

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