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Article

TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer

17 Sept 2021

Abstract excerpt

Sex disparity in cancer is so far inadequately considered, and components of its basis are rather unknown. We reveal that male versus female pancreatic cancer (PC) patients and mice show shortened survival, more frequent liver metastasis, and elevated hepatic metastasis-promoting gene expression. Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in...

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PMID: 34533565
DOI: 10.1084/jem.20210911

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