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Article

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.

Genes & development - 1 Mar 2006

Gocheva Vasilena, Zeng Wei, Ke Danxia, Klimstra David, Reinheckel Thomas, Peters Christoph, Hanahan Douglas, Joyce Johanna A

Abstract excerpt

Multiple types of degradative enzymes, including cathepsins of the cysteine protease family, have been implicated in the regulation of angiogenesis and invasion during cancer progression. Several cysteine cathepsins are up-regulated in a mouse model of pancreatic islet cell carcinogenesis (RIP1-Tag2), and tumor progression is impaired following their collective pharmacologic inhibition. Using null mutations of...

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Identifiers

PMID: 16481467
DOI: 10.1101/gad.1407406
PMCID: PMC1410800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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