Article

Tumor -Associated MUC1 Regulates TGF-β Signaling and Function in Pancreatic Ductal Adenocarcinoma

2020-05-01

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. Transforming Growth Factor Beta (TGF-β) is a cytokine that switches from a tumor-suppressor to a tumor promoter throughout tumor development, by a yet unknown mechanism. Tumor associated MUC1 (tMUC1) is aberrantly glycosylated and overexpressed in >80% of PDAs and is associated with poor prognosis. The cytoplasmic tail of MUC1 (MUC1-CT...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2707dc05-b123-556e-9461-c4187a615777
DOI: 10.1101/2020.04.29.068577

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumor -Associated MUC1 Regulates TGF-β Signaling and Function in Pancreatic Ductal AdenocarcinomaDOI 10.1101/2020.04.29.068577Read

The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGFSemantic proximity Read

Expression signature, prognosis value, and immune characteristics of MUC1 identified by pan-cancer analysisSemantic proximity Read

Muc1 ImmunotherapySemantic proximity Read

Mucin 1 Regulates Cox-2 Gene in Pancreatic CancerSemantic proximity Read

Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancySemantic proximity Read

MUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human CarcinomasSemantic proximity Read

MUC1 alters oncogenic events and transcription in human breast cancer cellsSemantic proximity Read

Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancerSemantic proximity Read

Prognostic Value of MUC1 and its Correlation with Tumor-Infiltrating Immune Cells in Breast CancerSemantic proximity Read

Integrative Analysis of MUC4 to Prognosis and Immune Infiltration in Pan-Cancer: Friend or Foe?Semantic proximity Read

MUC1 Protein Expression in Tumor Cells Regulates Transcription of Proinflammatory Cytokines by Forming a Complex with Nuclear Factor-κB p65 and Binding to Cytokine PromotersSemantic proximity Read

The Role of MUC1 in Renal Cell CarcinomaSemantic proximity Read