Article

Collagen type I promotes pancreatic tumor growth and limits immune cell infiltration

2026-01-10

Abstract excerpt

Solid tumors are often characterized by a dense extracellular matrix (ECM) that contributes to increased tissue stiffness. Collagen type I is the main component of the ECM and its abundance in tumors is frequently associated with poor prognosis. In vitro studies suggest that a high collagen density promotes tumor invasion and modulates immune responses. However, recent in vivo findings have questioned the pro-tumo...

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Literature Corpus work: fa89f870-2915-5b30-8500-31536b60666e
DOI: 10.64898/2026.01.09.698616

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