Article
DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells.
DNA repair - 1 Dec 2021
Shioi Seijiro, Shimamoto Akiyoshi, Song Yingxia, Hidaka Kyoko, Nakamura Maki, Take Ayumi, Hayashi Namiko, Takiguchi Soichi, Fujikane Ryosuke, Hidaka Masumi, Oda Shinya, Nakatsu Yoshimichi
Abstract excerpt
In prokaryotes and yeasts, DNA polymerase proofreading (PPR) and DNA mismatch repair (MMR) cooperatively counteracts replication errors leading to repeat sequence destabilization (i.e. insertions/deletions of repeat units). However, PPR has not thus far been regarded as a mechanism stabilizing repeat sequences in higher eukaryotic cells. In a human cancer cell line, DLD-1, which carries mutations in both MSH6 and...
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