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Elevated MSH2 MSH3 expression interferes with DNA metabolism in vivo

1 Nov 2023

Abstract excerpt

The Msh2-Msh3 mismatch repair (MMR) complex in Saccharomyces cerevisiae recognizes and directs repair of insertion/deletion loops (IDLs) up to ∼17 nucleotides. Msh2-Msh3 also recognizes and binds distinct looped and branched DNA structures with varying affinities, thereby contributing to genome stability outside post-replicative MMR through homologous recombination, double-strand break repair (DSBR) and the DNA...

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PMID: 37930834
DOI: 10.1093/nar/gkad934

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