Article
Mismatch repair is a double-edged sword in the battle against microsatellite instability
1 Jan 2022
Abstract excerpt
Roughly 3% of the human genome consists of microsatellites or tracts of short tandem repeats (STRs). These STRs are often unstable, undergoing high-frequency expansions (increases) or contractions (decreases) in the number of repeat units. Some microsatellite instability (MSI) is seen at multiple STRs within a single cell and is associated with certain types of cancer. A second form of MSI is characterised by...
Topics
Join the communities discussing this publication.