Article
Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro.
Nucleic acids research - 19 Sept 2017
Liu Dekang, Frederiksen Jane H, Liberti Sascha E, Lützen Anne, Keijzers Guido, Pena-Diaz Javier, Rasmussen Lene Juel
Abstract excerpt
DNA mismatch repair (MMR) is a highly-conserved DNA repair mechanism, whose primary role is to remove DNA replication errors preventing them from manifesting as mutations, thereby increasing the overall genome stability. Defects in MMR are associated with increased cancer risk in humans and other organisms. Here, we characterize the interaction between MMR and a proofreading-deficient allele of the human...
Topics
- DNA Methylation
- DNA Mismatch Repair
- DNA Polymerase III
- DNA Repair Enzymes
- Exodeoxyribonucleases
- HeLa Cells
- Humans
- Methylnitronitrosoguanidine
- Mutation