Article
The genetic basis and cell of origin of mixed phenotype acute leukaemia.
Nature - 1 Oct 2018
Alexander Thomas B, Gu Zhaohui, Iacobucci Ilaria, Dickerson Kirsten, Choi John K, Xu Beisi, Payne-Turner Debbie, Yoshihara Hiroki, Loh Mignon L, Horan John, Buldini Barbara, Basso Giuseppe, Elitzur Sarah, de Haas Valerie, Zwaan C Michel, Yeoh Allen, Reinhardt Dirk, Tomizawa Daisuke, Kiyokawa Nobutaka, Lammens Tim, De Moerloose Barbara, Catchpoole Daniel, Hori Hiroki, Moorman Anthony, Moore Andrew S, Hrusak Ondrej, Meshinchi Soheil, Orgel Etan, Devidas Meenakshi, Borowitz Michael, Wood Brent, Heerema Nyla A, Carrol Andrew, Yang Yung-Li, Smith Malcolm A, Davidsen Tanja M, Hermida Leandro C, Gesuwan Patee, Marra Marco A, Ma Yussanne, Mungall Andrew J, Moore Richard A, Jones Steven J M, Valentine Marcus, Janke Laura J, Rubnitz Jeffrey E, Pui Ching-Hon, Ding Liang, Liu Yu, Zhang Jinghui, Nichols Kim E, Downing James R, Cao Xueyuan, Shi Lei, Pounds Stanley, Newman Scott, Pei Deqing, Guidry Auvil Jaime M, Gerhard Daniela S, Hunger Stephen P, Inaba Hiroto, Mullighan Charles G
Abstract excerpt
Mixed phenotype acute leukaemia (MPAL) is a high-risk subtype of leukaemia with myeloid and lymphoid features, limited genetic characterization, and a lack of consensus regarding appropriate therapy. Here we show that the two principal subtypes of MPAL, T/myeloid (T/M) and B/myeloid (B/M), are genetically distinct. Rearrangement of ZNF384 is common in B/M MPAL, and biallelic WT1 alterations are common in T/M...
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