Article
Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia.
EBioMedicine - 1 Jun 2016
Liu Yuan-Fang, Wang Bai-Yan, Zhang Wei-Na, Huang Jin-Yan, Li Ben-Shang, Zhang Ming, Jiang Lu, Li Jian-Feng, Wang Ming-Jie, Dai Yu-Jun, Zhang Zi-Guan, Wang Qiang, Kong Jie, Chen Bing, Zhu Yong-Mei, Weng Xiang-Qin, Shen Zhi-Xiang, Li Jun-Min, Wang Jin, Yan Xiao-Jing, Li Yan, Liang Ying-Min, Liu Li, Chen Xie-Qun, Zhang Wang-Gang, Yan Jin-Song, Hu Jian-Da, Shen Shu-Hong, Chen Jing, Gu Long-Jun, Pei Deqing, Li Yongjin, Wu Gang, Zhou Xin, Ren Rui-Bao, Cheng Cheng, Yang Jun J, Wang Kan-Kan, Wang Sheng-Yue, Zhang Jinghui, Mi Jian-Qing, Pui Ching-Hon, Tang Jing-Yan, Chen Zhu, Chen Sai-Juan
Abstract excerpt
Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) were investigated using next-generation sequencing and copy number alteration analysis. Recurrent gene mutations and fusions were tested in an additional 87 adult and 93 pediatric patients. Among the 29 newly identified in-frame gene fusions, those involving MEF2D and ZNF384 were clinically relevant and were...
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