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Article

ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma.

Cell death & disease - 18 Jul 2024

Vázquez-Cabrera Guillermo, Škandík Martin, Roncier Noémie, Real Oualit Farah, Cruz De Los Santos Mireia, Baleviciute Austeja, Cheray Mathilde, Joseph Bertrand

Abstract excerpt

Glioblastoma is a highly aggressive brain tumour that creates an immunosuppressive microenvironment. Microglia, the brain's resident immune cells, play a crucial role in this environment. Glioblastoma cells can reprogramme microglia to create a supportive niche that promotes tumour growth. However, the mechanisms controlling the acquisition of a transcriptome associated with a tumour-supportive microglial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39019900
DOI: 10.1038/s41419-024-06903-3
PMCID: PMC11255298

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