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Article

Employing chemical synthesis to study the structure and function of colibactin, a "dark matter" metabolite.

Natural product reports - 18 Nov 2020

Williams Peyton C, Wernke Kevin M, Tirla Alina, Herzon Seth B

Abstract excerpt

Covering: 2015 to 2020 The field of natural products is dominated by a discovery paradigm that follows the sequence: isolation, structure elucidation, chemical synthesis, and then elucidation of mechanism of action and structure-activity relationships. Although this discovery paradigm has proven successful in the past, researchers have amassed enough evidence to conclude that the vast majority of nature's...

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Identifiers

PMID: 33174565
DOI: 10.1039/d0np00072h
PMCID: PMC7700718

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