Article
Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.
Journal of cachexia, sarcopenia and muscle - 1 Dec 2021
Lakshman Kumar Preeti, Wilson Ava C, Rocco Alison, Cho Michael H, Wan Emily, Hobbs Brian D, Washko George R, Ortega Victor E, Christenson Stephanie A, Li Xingnan, Wells J Michael, Bhatt Surya P, DeMeo Dawn L, Lutz Sharon M, Rossiter Harry, Casaburi Richard, Rennard Stephen I, Lomas David A, Labaki Wassim W, Tal-Singer Ruth, Bowler Russel P, Hersh Craig P, Tiwari Hemant K, Dransfield Mark, Thalacker-Mercer Anna, Meyers Deborah A, Silverman Edwin K, McDonald Merry-Lynn N
Abstract excerpt
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass index (BMI) and lung function. We tested the hypothesis genetic variation is associated with weight loss in COPD using a genome-wide association study approach. METHODS: Participants with COPD (N = 4308) from three...
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