Article
Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.
Journal of cachexia, sarcopenia and muscle - 1 Jun 2017
McDonald Merry-Lynn Noelle, Won Sungho, Mattheisen Manuel, Castaldi Peter J, Cho Michael H, Rutten Erica, Hardin Megan, Yip Wai-Ki, Rennard Stephen I, Lomas David A, Wouters Emiel F M, Agusti Alvar, Casaburi Richard, Lange Christoph P, O'Connor George, Hersh Craig P, Silverman Edwin K
Abstract excerpt
BACKGROUND: There have been a number of candidate gene association studies of cancer cachexia-related traits, but no genome-wide association study (GWAS) has been published to date. Cachexia presents in patients with a number of complex traits, including both cancer and COPD. The objective of the current investigation was to search for a shared genetic aetiology for change in body mass index (ΔBMI) among cancer...
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