Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.

doi:10.1002/jcsm.70293

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Article

Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.

Journal of cachexia, sarcopenia and muscle - 1 Jun 2026

Chiles Joe W, Rocco Alison, Srinivasasainagendra Vinodh, Rossiter Harry B, Casaburi Richard, Thalacker-Mercer Anna, Wells J Michael, Wan Emily S, Silverman Edwin K, Cho Michael H, Hersh Craig P, Psaty Bruce M, Gharib Sina A, Gao Yan, O'Connor George T, Lange Leslie A, Rich Stephen S, Manichaikul Ani W, Barr R Graham, Ortega Victor E, Meyers Deborah A, Smith Albert V, Tiwari Hemant K, McDonald Merry-Lynn N

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood. We performed this whole genome sequencing (WGS) analysis to identify genetic risk variants for WL in COPD. METHODS: We studied 16 972...

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PMID: 42026014
DOI: 10.1002/jcsm.70293
PMCID: PMC13106028

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PDZRN3
HCN1

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