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Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs.

PLoS genetics - 1 Oct 2020

Hwang Liang-Dar, Tubbs Justin D, Luong Justin, Lundberg Mischa, Moen Gunn-Helen, Wang Geng, Warrington Nicole M, Sham Pak C, Cuellar-Partida Gabriel, Evans David M

Abstract excerpt

Indirect parental genetic effects may be defined as the influence of parental genotypes on offspring phenotypes over and above that which results from the transmission of genes from parents to their children. However, given the relative paucity of large-scale family-based cohorts around the world, it is difficult to demonstrate parental genetic effects on human traits, particularly at individual loci. In this...

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Identifiers

PMID: 33104719
DOI: 10.1371/journal.pgen.1009154
PMCID: PMC7646364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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