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Aurora A Kinase (AURKA) is required for male germline maintenance and regulates sperm motility in the mouse.

14 Sept 2021

Abstract excerpt

Aurora A kinase (AURKA) is an important regulator of cell division and is required for assembly of the mitotic spindle. We recently reported the unusual finding that this mitotic kinase is also found on the sperm flagellum. To determine its requirement in spermatogenesis, we generated conditional knockout animals with deletion of the Aurka gene in either spermatogonia or spermatocytes to assess its role in...

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PMID: 34518881
DOI: 10.1093/biolre/ioab168

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