Article
TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer.
Proceedings of the National Academy of Sciences of the United States of America - 21 Sept 2021
Agarwal Neeraj, Rinaldetti Sebastien, Cheikh Bassem B, Zhou Qiong, Hass Evan P, Jones Robert T, Joshi Molishree, LaBarbera Daniel V, Knott Simon R V, Cech Thomas R, Theodorescu Dan
Abstract excerpt
Bladder cancer (BC) has a 70% telomerase reverse transcriptase (TERT or hTERT in humans) promoter mutation prevalence, commonly at -124 base pairs, and this is associated with increased hTERT expression and poor patient prognosis. We inserted a green fluorescent protein (GFP) tag in the mutant hTERT promoter allele to create BC cells expressing an hTERT-GFP fusion protein. These cells were used in a...
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