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An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype

12 Sept 2021

Abstract excerpt

BACKGROUND: Neutrophilic asthma (NA) is a clinically important asthma phenotype, the cellular and molecular basis of which is not completely understood. Airway macrophages are long-lived immune cells that exert important homeostatic and inflammatory functions which are dysregulated in asthma. Unique transcriptomic programmes reflect varied macrophage phenotypes in vitro. We aimed to determine whether airway...

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PMID: 34510493
DOI: 10.1111/all.15087

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