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Article

Altered stress hormone levels affect in vivo vascular function in the hAPP23+/- overexpressing mouse model of Alzheimer's disease.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2021

Hendrickx Jhana O, De Moudt Sofie, Van Dam Debby, De Deyn Peter Paul, Fransen Paul, De Meyer Guido R Y

Abstract excerpt

Alzheimer's disease (AD) has long been considered a brain-specific dementia syndrome. However, in recent decades, the occurrence of cardiovascular (CV) disease in the progression of AD has been confirmed by increasing epidemiological evidence. In this study, we conducted an in-depth cardiovascular characterization of a humanized amyloid precursor protein (APP) overexpressing mouse model (hAPP23+/-), which...

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Source

Identifiers

PMID: 34506227
DOI: 10.1152/ajpheart.00254.2021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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