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Article

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer's disease model.

Neurobiology of disease - 1 Aug 2014

Ongali Brice, Nicolakakis Nektaria, Tong Xin-Kang, Aboulkassim Tahar, Papadopoulos Panayiota, Rosa-Neto Pedro, Lecrux Clotilde, Imboden Hans, Hamel Edith

Abstract excerpt

Angiotensin II (AngII) receptor blockers that bind selectively AngII type 1 (AT1) receptors may protect from Alzheimer's disease (AD). We studied the ability of the AT1 receptor antagonist losartan to cure or prevent AD hallmarks in aged (~18months at endpoint, 3months treatment) or adult (~12months at endpoint, 10months treatment) human amyloid precursor protein (APP) transgenic mice. We tested learning and...

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Identifiers

PMID: 24807206
DOI: 10.1016/j.nbd.2014.04.018

Genes

APP
SOD1
SOD2
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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