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Article

Therapeutic effect of human ApoA-I-Milano variant in aged transgenic mouse model of Alzheimer's disease.

British journal of pharmacology - 1 Aug 2023

Solé Montse, Marazuela Paula, Castellote Laura, Bonaterra-Pastra Anna, Giménez-Llort Lydia, Hernández-Guillamon Mar

Abstract excerpt

BACKGROUND AND PURPOSE: Therapies based on apolipoprotein A-I (ApoA-I), classically tested for cardiovascular diseases, were recently proposed for Alzheimer's disease (AD). Based on a drug reprofiling approach, our objective was to explore the use of a natural variant of ApoA-I form, ApoA-I-Milano (M), as a treatment for AD. ApoA-I-M contains the R173C mutation, and confers protection against atherosclerosis...

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PMID: 36872299
DOI: 10.1111/bph.16065

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