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Article

Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry.

Cancer research - 1 May 2021

Sapkota Yadav, Qin Na, Ehrhardt Matthew J, Wang Zhaoming, Chen Yan, Wilson Carmen L, Estepp Jeremie, Rai Parul, Hankins Jane S, Burridge Paul W, Jefferies John L, Zhang Jinghui, Hudson Melissa M, Robison Leslie L, Armstrong Gregory T, Mulrooney Daniel A, Yasui Yutaka

Abstract excerpt

Cardiomyopathy occurs at significantly higher rates in survivors of childhood cancer than the general population, but few studies have evaluated racial or ethnic disparities, and none have assessed potential genetic factors contributing to this outcome. In this study, childhood cancer survivors of African ancestry exposed to cardiotoxic therapies (anthracyclines and/or heart radiotherapy; n = 246) were compared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33288658
DOI: 10.1158/0008-5472.CAN-20-2675
PMCID: PMC8137513

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