A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.

doi:10.1038/ng.2796

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Article

A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.

Nature genetics - 1 Dec 2013

Levine David M, Ek Weronica E, Zhang Rui, Liu Xinxue, Onstad Lynn, Sather Cassandra, Lao-Sirieix Pierre, Gammon Marilie D, Corley Douglas A, Shaheen Nicholas J, Bird Nigel C, Hardie Laura J, Murray Liam J, Reid Brian J, Chow Wong-Ho, Risch Harvey A, Nyrén Olof, Ye Weimin, Liu Geoffrey, Romero Yvonne, Bernstein Leslie, Wu Anna H, Casson Alan G, Chanock Stephen J, Harrington Patricia, Caldas Isabel, Debiram-Beecham Irene, Caldas Carlos, Hayward Nicholas K, Pharoah Paul D, Fitzgerald Rebecca C, Macgregor Stuart, Whiteman David C, Vaughan Thomas L

Abstract excerpt

Esophageal adenocarcinoma is a cancer with rising incidence and poor survival. Most such cancers arise in a specialized intestinal metaplastic epithelium, which is diagnostic of Barrett's esophagus. In a genome-wide association study, we compared esophageal adenocarcinoma cases (n = 2,390) and individuals with precancerous Barrett's esophagus (n = 3,175) with 10,120 controls in 2 phases. For the combined case...

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Identifiers

PMID: 24121790
DOI: 10.1038/ng.2796
PMCID: PMC3840115

Genes

BARX1
CRTC1
FOXF1
FOXP1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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