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Article

Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4.

Frontiers in immunology - 1 Jan 2021

Burkard Tobias, Dreis Caroline, Herrero San Juan Martina, Huhn Meik, Weigert Andreas, Pfeilschifter Josef M, Radeke Heinfried H

Abstract excerpt

Although the human immune response to cancer is naturally potent, it can be severely disrupted as a result of an immunosuppressive tumor microenvironment. Infiltrating regulatory T lymphocytes contribute to this immunosuppression by inhibiting proliferation of cytotoxic CD8+ T lymphocytes, which are key to an effective anti-cancer immune response. Other important contributory factors are thought to include...

Read the complete abstract on PubMed

Topics

ADP-ribosyl Cyclase 1
Apyrase
CD8-Positive T-Lymphocytes
Cell Differentiation
Cell Movement
Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Interleukin-1 Receptor-Like 1 Protein

Interleukin-33

Lymphocytes, Tumor-Infiltrating

Membrane Glycoproteins

Phenotype

Programmed Cell Death 1 Receptor

Receptors, CXCR4

Signal Transduction

Sphingosine-1-Phosphate Receptors

Tumor Microenvironment

Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 34504486
DOI: 10.3389/fimmu.2021.668884
PMCID: PMC8421764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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