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Article

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.

International journal of cancer - 1 Nov 2009

Weigert Andreas, Schiffmann Susanne, Sekar Divya, Ley Stephanie, Menrad Heidi, Werno Christian, Grosch Sabine, Geisslinger Gerd, Brüne Bernhard

Abstract excerpt

A challenging task of the immune system is to fight cancer cells. However, a variety of human cancers educate immune cells to become tumor supportive. This is exemplified for tumor-associated macrophages (TAMs), which are polarized towards an anti-inflammatory and cancer promoting phenotype. Mechanistic explanations, how cancer cells influence the macrophage phenotype are urgently needed to address potential...

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Identifiers

PMID: 19618460
DOI: 10.1002/ijc.24594

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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