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Article

A Novel Function of Sphingolipid Signaling via S1PR3 in Hematopoietic and Leukemic Stem Cells

1 Dec 2020

Abstract excerpt

Abstract Summary: In this issue of Blood Cancer Discovery, Xie and colleagues describe a novel function of sphingosine-1-phosphate receptor 3 (S1PR3) to regulate myeloid differentiation and activate inflammatory programs in both human hematopoietic stem cells and leukemic stem cells. They propose S1PR3 as a major downstream signaling pathway of a TNFα–NF-κB axis in this study and unlock potential therapeutic...

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PMID: 34661148
DOI: 10.1158/2643-3230.bcd-20-0200

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