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Article

Intron retention-induced neoantigen load correlates with unfavorable prognosis in multiple myeloma.

Oncogene - 1 Oct 2021

Dong Chuanpeng, Cesarano Annamaria, Bombaci Giuseppe, Reiter Jill L, Yu Christina Y, Wang Yue, Jiang Zhaoyang, Zaid Mohammad Abu, Huang Kun, Lu Xiongbin, Walker Brian A, Perna Fabiana, Liu Yunlong

Abstract excerpt

Neoantigen peptides arising from genetic alterations may serve as targets for personalized cancer vaccines and as positive predictors of response to immune checkpoint therapy. Mutations in genes regulating RNA splicing are common in hematological malignancies leading to dysregulated splicing and intron retention (IR). In this study, we investigated IR as a potential source of tumor neoantigens in multiple myeloma...

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Share to Antigens, Neoplasm
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Analysis, RNA

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Source

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Identifiers

PMID: 34504297
DOI: 10.1038/s41388-021-02005-y
PMCID: PMC8426332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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